KMID : 0043319940170060467
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Archives of Pharmacal Research 1994 Volume.17 No. 6 p.467 ~ p.469
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Synthesis of Mannich Bases of Antineoplaston A10 and their Antitumor Activity
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Choi Bo-Gil
Seo Hee-Kyoung Chung Byung-Ho Choi Sang-Un Lee Chong-Ock
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Abstract
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Some Mannich bases of Antineoplaston A10 which is antitumor agent under chlinical investigation were synthesized and tested fro cytotoxicity. The tested compounds (2a, 2b, 2d) showed good activity comparable to that of carboplatin.
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KEYWORD
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Antineoplastic peptides, Antineplaston A10, Piperidinedione derivatives, Mannich base, Antitumor agent
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