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KMID : 0043319940170060467
Archives of Pharmacal Research
1994 Volume.17 No. 6 p.467 ~ p.469
Synthesis of Mannich Bases of Antineoplaston A10 and their Antitumor Activity
Choi Bo-Gil

Seo Hee-Kyoung
Chung Byung-Ho
Choi Sang-Un
Lee Chong-Ock
Abstract
Some Mannich bases of Antineoplaston A10 which is antitumor agent under chlinical investigation were synthesized and tested fro cytotoxicity. The tested compounds (2a, 2b, 2d) showed good activity comparable to that of carboplatin.
KEYWORD
Antineoplastic peptides, Antineplaston A10, Piperidinedione derivatives, Mannich base, Antitumor agent
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